. Cytochrome P450 2D6 is the most important enzyme liable for the transformation of codeine to morphine and P450 3A4 is the primary enzyme mediating the conversion of codeine to norcodeine
Will not use with every other drug containing acetaminophen without inquiring your health care provider or pharmacist to start with. Acetaminophen is in many nonprescription and prescription drugs (such as pain/fever prescription drugs or cough-and-cold solutions).
Extended-expression utilization of promethazine/phenylephrine/codeine may well have an effect on your ability to become pregnant or have a husband or wife pregnant. Talk with your Health care company When you've got any concerns.
投与方法は経口で、形状は錠、散、シロップがある。錠剤ではコデインはしばしばアセトアミノフェン、アスピリン、イブプロフェンと共に調合される。これらの組み合わせは、それぞれ単体での使用よりも良い疼痛コントロールが可能となる。
In the situation on the toddler Demise, the mom was found to be a CYP2D6 extremely-quick metabolizer, which perhaps brought about greater levels of morphine secreted into the breast milk leading to the infant’s death.
Stimulation may be apparent, particularly in kids and geriatric individuals. Convulsions may perhaps seldom arise. A paradoxical-kind response has actually been described in youngsters receiving solitary doses of 75 mg to a hundred twenty five mg orally, characterized by hyperexcitability and nightmares.
Your medical professional is the greatest human being to recommend you on whether codeine is the right medicine for you, just how much you need and how long to acquire it for.
While you are taking this drugs, it is very important that the healthcare Experienced know For anyone who is getting any in the medicines listed down below. The subsequent interactions are actually selected on The idea in their possible importance and are not check here automatically all-inclusive.
In addition to its needed consequences, a medication could cause some undesirable effects. Despite the fact that not most of these Uncomfortable side effects might come about, when they do happen They might need to have healthcare notice.
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Browse the Medication Guide supplied by your pharmacist before you start having acetaminophen/codeine and every time you can get a refill. When you've got any questions, ask your medical professional or pharmacist.
Info Within this leaflet is general in character and should not take the put of recommendation from your health care supplier
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